ABSTRACT
Background: Malaria is the primary cause of hospitalization in Ctte d'Ivoire. Early treatment is one of the strategies to control this illness. However; the spread of resistance of Plasmodium falciparum to antimalarial drugs can seriously compromise this strategy. Objectives: The aim of this study was to assess the in vitro susceptibility of P. falciparum to monodesethylamodiaquine and aminoalcohols in Abidjan (Ctte d'Ivoire). Methods: We assessed the in vitro susceptibility of isolates collected from patients with uncomplicated malaria by using the WHO optical microtest technique. Results: The proportions of resistance to monodesethylamodiaquine; m?floquine and halofantrine were 12.5; 15.6and 25.9; respectively. For quinine; none of isolates showed evidence of in vitro resistance. However; two isolates (6.1) had IC 50 values above 300 nM. The IC 50 of each drug was positively and significantly correlated to that of the other three drugs; and the correlation was higher between halofantrine and mefloquine. Conclusions: Our results showed that the in vitro chloroquine resistance reported in previous studies has been extended to other antimalarial drugs investigated in this study except for quinine. Therefore; it is necessary to implement a long-term monitoring system of antimalarial drug resistance. 15.6and 25.9; respectively. For quinine; none of isolates showed evidence of in vitro resistance. However; two isolates (6.1) had IC 50 values above 300 nM. The IC 50 of each drug was positively and significantly correlated to that of the other three drugs; and the correlation was higher between halofantrine and mefloquine. Conclusions: Our results showed that the in vitro chloroquine resistance reported in previous studies has been extended to other antimalarial drugs investigated in this study except for quinine. Therefore; it is necessary to implement a long-term monitoring system of antimalarial drug resistance
Subject(s)
Drug Resistance , Plasmodium falciparumABSTRACT
Otomycosis is fre q u e n t ly encountered in tropical and subtropical zones. In Ivory Coast diagnosis of this disease is often based solely on the clinical symptoms. The objectives of this study were to determine the prevalence; predisposing factors; and etiologic agents associated with otomycosis at the Treichville University Hospital Center in Abidjan; Ivory Coast. M y c o l ogical examinations we re perfo rmed on specimens obtained from 115 patients presenting with external otitis at the d'Oto-Rhino-Laryngology Department. Fungi-positive cultures were obtained in 49 patients for an overall otomycosis prevalence of 42.6 (95Confidence Interval (CI); 34.4-52.2). Univa ri ate analysis showed that the predisposing fa c t o rs for otomycosis we re frequent swimming in natural or artificial pools (Relative Risk (RR) 3.7; CI 1.7-8.1); daily ear cleaning (RR 3.5; CI 1.8-6.8) and excessive use of eardrops containing antibiotics and corticoids (RR = 9.3; IC95= 4.3-20.1). The most common etiologic agents were Aspergillus fl avus (20.4); Candida albicans (16.3); Candida parapsilosis (14.3); and A s p e rgillus niger (12.2). A combination of two agents was found in five cases. These data show that otomycosis is endemic in Ivo ry Coast. Manage m e n t of otomycosis must include mycological examination for diagnosis as well as changing behavior patterns leading to infection